Advanced Organic Chemistry

Advanced Organic Chemistry
Synthetic aspects of organic chemistry; oxidations, reductions, concerted reactions, stereoselectivity, synthetic equivalents, protecting groups. Examples of natural product total synthesis.
 Hours3.0 Credit, 3.0 Lecture, 0.0 Lab
 PrerequisitesCHEM 352; or CHEM 352M
 ProgramsContaining CHEM 553
Course Outcomes

Outcome 1

Formulate a retrosynthetic analysis and propose a total synthesis route for a previously un-synthesized complex natural product.

Outcome 2

Apply protecting group strategies in feasible routes to complex natural products and/or other organic molecules of biological or theoretical interest.

Outcome 3

Recognize and be able to apply standard methods for carbon-carbon bond forming reactions including: alkylation of nucleophilic carbon; reactions of carbanions with carbonyl groups; reactions involving transition metals; reactions of compounds of boron, silicon, and tin; and cycloadditions.

Outcome 4

Recognize and be able to apply standard methods for carrying out the following types of synthetic transformations: reductions of carbonyls and other functional groups, oxidations, electrophilic additions, aromatic substitution reactions.

Outcome 5

Predict reaction mechanisms for the reaction types listed in outcomes 3 and 4.